- How Safe Is Safe Enough? Radiation Risk for a Human Mission to Mars FA Cucinotta , M-HY Kim , LJ Chappell , JL Huff (PLoS ONE 8(10): e74988. doi:10.1371/journal.pone.0074988)
Posted October 16, 2013
- Monte Carlo Transport Codes for use in the Space Radiation Environment (PDF) - Lawrence Pinsky
Posted February 27, 2015
- Epigenetic Memory of Space Radiation Exposure (PDF) - Elizabeth M. Kennedy, Karen N. Conneely and Paula M. Vertino
Posted July 30, 2014
- NASA Space Radiation Laboratory (PDF) - D.I. Lowenstein, P. Guida, A. Rusek
Posted March 1, 2011
- The Natural Space Ionizing Radiation Environment (PDF) - Patrick M. O'Neill
Posted June 14, 2001
- Summary of an integrated experimental and computational approach to study the effects of heavy ion exposures on skin
(PDF) - Jake Pirkkanen, Claere von Neubeck, Marianne B. Sowa
Posted June 25, 2014
- MALDI-MSI: Biomarker Discovery for Radiation Exposures (PDF) - Claire L. Carter, Thomas J. MacVittie, Maureen A. Kane
Posted March 24, 2014
- The Bystander Effect of Space Radiation (PDF) - Edouard Azzam and Jason Domogauer
Posted March 10, 2014
- The Effects of Space Radiation-changed MiRNAs on Tumorigenesis – Ya Wang, Ph.D. ( PDF)
- Development of Monte Carlo Track Structure Codes – Larry Toburen (PDF)
- Microdosimetry and Detector Responses – Leslie A. Braby (PDF)
- Monte Carlo Track Simulations – Michael Dingfelder (PDF)
Posted February 6, 2014
- Lung Cancer Explorer - Yang Xie (PDF)
Posted December 18, 2013
Posted November 1, 2013
- The Evolution of Risk Cross Section - Stanley B. Curtis (PDF)
Posted November 1, 2013
The Local Effect Model – Principles and Applications - Thomas Friedrich, Marco Durante, and Michael Scholz (PDF)
Posted May 7, 2013
Signal transduction processes in response to low dose ionizing radiation doses expected during space flight –
David Boothman, Tracy Criswell, Eva Goetz, Dmitri Klokov, Yonglong Zou, and Xiuquan Luo (PDF)
Posted May 6, 2013
- History of the Heavy Ion Therapy at GSI – Gerhard Kraft (PDF)
Posted April 29, 2013
- Particle Irradiation Data Ensemble – Thomas Friedrich and Michael Scholz (PDF)
Posted March 6, 2013
- Fluence Rates, Delta Rays and Cell Nucleus Hit Rates from Galactic Cosmic Rays – Stanley B. Curtis (PDF)
Posted February 28, 2013
- Space Radiation Cancer Risk Projections and Uncertainties – 2012 – Francis Cucinotta, Myung-Hee, Y. Kim,
Lori J. Chappell (PDF)
Posted February 25, 2013
- NSCR – NASA Space Cancer Risk Integrated Tools, Web Server Release 1.0 – F.A. Cucinotta (PDF)
Posted January 31, 2013
- A Note On The Dose-Rate-Effectiveness Factor and its Progeny DDREF - R.J.M. Fry (PDF)
Posted January 9, 2013
- Interpreting Microdosimetric Spectra – J.F. Dicello and F.A Cucinotta (PDF)
Posted December 10, 2012
- Exploration Systems Radiation Monitoring Requirements – Ronald Turner (PDF)
- Radiation Quality and Space Radiation Risks – Francis Cucinotta (swf)
- Kinetics, Systems Biology and other Models – Francis Cucinotta (swf)
Posted October 30, 2012
- Physics of Protons for Patient Treatment - Andrew J. Wroe, Jerry D. Slater, James M. Slater (pdf)
- Rationale for, and Development of, the World's First Hospital-based Proton Therapy System at Loma Linda University Medical Center - James. Slater (pdf)
- Clinical Proton Therapy at Loma Linda University Medical Center - Jerry D. Slater (pdf)
Posted September 20, 2012
- TRiP98 (TReatment PlannIng for Particles) - M. Kraemer (pdf)
Posted September 10, 2012
- Neurogenesis – John Fike (swf)
- Radiation Response of Stem Cells and Neurons – John Fike (swf)
- Radiation Effects in the Central Nervous System (updated) – M. Kerry O’Banion (swf)
Posted August 15, 2012
- Essentials of Mammalian DNA Repair – Paul Wilson (swf)
Posted July 3, 2012
Posted June 15, 2012
- Brooks, A.
The Use of Biomarkers to Predict Radiation Dose and Risk During Space Flights (PDF)
Posted June 18, 2012
- Using Flow Cytometry to Detect High-LET Radiation Induced Apoptosis and Necrosis – Peter Guida (swf)
- Heavy Ions and Shielding Physics – Lawrence Heilbronn (swf)
- Detection Methods – Lawrence Heilbronn (swf)
- Oxidative Stress – Peter O’Neill (swf)
- Radiation Chemistry and DNA Damage – Peter O’Neill (swf)
Posted May 1, 2012
- Radiation Protection – Walter Schimmerling (swf)
Posted May 29, 2012
- The role of innate and adaptive immune system in the tissue responses to ionizing radiation – Sandra Demaria swf
- Radiation Track Structure – Dudley T. Goodhead (swf)
- Neutron Properties and Definitions – Lawrence Heilbronn (swf)
- Transgenic Mouse Models and Novel Imaging Approaches - David Kirsch (swf)
- Microgravity Effects– Gregory Nelson Slides swf
- High/Low LET Microbeams, Gerhard Randers-Pehrson – (swf)
- Radiation-Induced Leukemia- Michael Weil swf
- Animal Studies/Radiation Carcinogenesis– Michael Weil (swf)
- Animal Studies/Genetics - Michael Weil (swf)
- Accelerator-based Space Physics - Cary Zeitlin, Lawrence Heilbronn, John Norbury (swf)
Posted March 23, 2012
- Physics Summary – Lawrence Heilbronn (swf)
- Radiation-Induced Non-Targeted Effects – Edouard Azzam (swf)
Posted March 29, 2012
In the News Archive
Particle Radiation-Induced Non-targeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells
Goukassian DA, Sasi SP, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, Enderling H, Yan X. Stem Cell International, May 2015 [In press].
Our studies show that exposure to single low-dose proton (90 cGy, 1 GeV) or iron (15 cGy, 1 GeV/n) radiation culminated in persistent IR-induced DNA damage in BM-EPCs over a period of one month; increased levels of cytokine and chemokine expression over 24 h along with a cyclical increase in apoptosis over 28 days post-IR. This may lead to BM-EPC dysfunction and eventually contribute to the increased risk for development of cardiovascular and neurodegenerative diseases. Therefore, identifying the role of specific cytokines responsible for IR-induced NTE in BM may allow development of mitigating factors to prevent long-term and cyclical loss of stem and progenitors cells in the BM milieu.
Persistent oxidative stress in human neural stem cells exposed to low fluences of charged particles
Baulch JE, Craver BM, Tran KK, Yu L, Chmielewski N, Allen BD, Limoli CL. Redox Biol. 2015 Aug 11;5:24-32. Epub 2015 Mar 11.
Summary: In this study we investigated whether space relevant fluences of charged particles caused oxidative stress in cultures of human neural stem cells that was proportional to the microdosimetric properties of the incident particle. Dose and temporal responses for radiation-induced oxidative stress were probed through the use of intracellular fluorogenic dyes that exhibit relative specificity for certain reactive species. Increased fluorescent signals derived from the oxidation of selected redox sensitive dyes provided a quantitative measure of oxidative stress after exposure. Data showed that the total dose, rather than particle energy and/or LET was the predominate factor dictating the extent and duration of oxidative stress in irradiated populations of human neural stem cells.
A New Approach to Reduce Uncertainties in Space Radiation Cancer Risk Predictions.
Cucinotta, F.S. 2015;PLOS ONE 10.1371/journal.pone.0120717
The prediction of space radiation induced cancer risk carries large uncertainties with two of the largest uncertainties being radiation quality and dose-rate effects. In risk models the ratio of the quality factor (QF) to the dose and dose-rate reduction effectiveness factor (DDREF) parameter is used to scale organ doses for cosmic ray proton and high charge and energy (HZE) particles to a hazard rate for γ-rays derived from human epidemiology data.. Here I report on an analysis of a maximum QF parameter and its uncertainty using mouse tumor induction data. Because experimental data for risks at low doses of γ-rays are highly uncertain which impacts estimates of maximum values of relative biological effectiveness (RBEmax), I developed an alternate QF model, denoted QFγAcute where QFs are defined relative to higher acute γ-ray doses (0.5 to 3 Gy). The alternate model reduces the dependence of risk projections on the DDREF, however a DDREF is still needed for risk estimates for high-energy protons and other primary or secondary sparsely ionizing space radiation components. In addition, I discuss how a possible qualitative difference leading to increased tumor lethality for HZE particles compared to low LET radiation and background tumors remains a large uncertainty in risk estimates.
Ionizing radiation stimulates expression of pro-osteoclastogenic genes in marrow and skeletal tissue
Alwood JS, Shahnazari M, Chicana B, Schreurs AS, Kumar A, Bartolini A, Shirazi-Fard Y, Globus RK. J Interferon Cytokine Res. 2015 Mar 3. [Epub ahead of print]
Irradiation causes a very rapid loss of mineralized bone tissue via increased resorption by osteoclasts. In this study, adult mice were exposed to HZE (56Fe) or 137Cs radiation to evaluate expression levels of genes known to mediate osteoclastogenesis. This work shows a time-dependent, radiation-induced increase in skeletal expression of Rankl, the obligate cytokine for osteoclast differentiation, as well as other pro-resorption cytokines (Mcp1, Tnf, Csf1, Il6), markers of osteoclast activation (Acp5, Ctk, NfatC1), and oxidative stress responses (nfe2l2). These molecular responses to radiation preceded (< 3 days) the manifestation of bone loss (3–7 days). The findings have relevance to skeletal fragility caused by radiation exposure either on Earth or in space.
Space radiation risks to the central nervous system (Review)
Cucinotta, F.A., Alp, M., Sulzman, F.M., Wang, M. Life Sci. Space Res, 2014;2:54–69
In this report we summarize recent space radiobiology studies of CNS effects from particle accelerators simulating space radiation using experimental models, and make a critical assessment of their relevance with respect to doses and the dose rates to be incurred on a Mars Mission. Prospects for understanding dose, dose-rate and radiation quality dependencies of CNS effects and extrapolation to human risk assessments are described.
Measurements of the neutron spectrum in transit to Mars on the Mars Science Laboratory
Köhler J, Ehresmann B, Zeitlin C, Wimmer-Schweingruber RF,J, Böttcher S, Böhm E, Burmeister S, Guo J, Lohf H, Martin C, Posner A, Rafkin S.
Life Sci Space Res. 2015 Mar 24. [Article in Press] Article citation (from SPACELINE):
The Mars Science Laboratory spacecraft, containing the Curiosity rover, was launched to Mars on 26 November 2011. Although designed for measuring the radiation on the surface of Mars, the Radiation Assessment Detector (RAD) used this unique opportunity to measure the radiation environment inside the spacecraft during the 253-day cruise to Mars.RAD measures neutral particles with two scintillators enclosed by an anti-coincidence. One of the scintillators has a high-Z and therefore a high sensitivity for gamma-rays, the other scintillator has a high proton content and therefore a high sensitivity for neutrons. In this work an inversion method is applied to the RAD neutral particle measurements to obtain the neutron and gamma spectra as well as neutron dose and dose equivalent.
Evaluation of the new radiation belt AE9/AP9/SPM model for a cislunar mission
Badavi FF, Walker SA, Santos Koos LM. Acta Astronaut. 2014;102:156-68.
A multi-vehicle mission is planned for the epoch of February 2020 from LEO to the Earth–moon Lagrange-point two (L2), located approximately 63,000km beyond the orbit of the Earth–Moon binary system. During the LEO–GEO transit, the crew and cargo vehicles will encounter exposure from trapped particles and attenuated GCR, followed by free space exposure due to GCR and SEP. In this work, the amount of exposure acquired within the trapped field, along the design trajectory of the crew vehicle, using the new AE9/AP9/SPM model is evaluated against the older AE8/AP8 model. The analysis is then extended to the GCR dominated en-route, cislunar L2 space and return trajectories in order to provide cumulative exposure estimates for the duration of the mission.
Validation of the new trapped environment AE9/AP9/SPM at low Earth orbit
Badavi FF. Adv Space Res. 2014;54(6):917-28.
One goal of this paper is to validate the older AE8/AP8 and the new AE9/AP9/SPM trapped radiation models against ISS dosimetric measurements for a silicon based detector, and to assess the improvements in the AE9/AP9/SPM model as compared to AE8/AP8 using both isotropic and anisotropic spectra. For angular validation AP8 and AP9 are compared with measurements from the compact environment anomaly sensor (CEASE). science instrument package, flown June 2000–July 2006. Particular emphasis is put on the validation of proton flux profiles at differential 40 MeV and integral >40 MeV, in the vicinity of the South Atlantic Anomaly, where protons exhibit east–west (EW) anisotropy and have a relatively narrow pitch angle distribution.
Data integration reveals key homeostatic mechanisms following low dose radiation exposure
Susan C. Tilton, Melissa M. Matzke, Marianne B. Sowa, David L. Stenoien, Thomas J. Weber, William F. Morgan, and Katrina M. Waters, Toxicol Appl Pharmacol. 2015 Feb 2. pii: S0041-008X(15)00042-3. doi: 10.1016/j.taap.2015.01.019. [Epub ahead of print].
This study develops a systems approach to define pathways regulated by low dose radiation exposures and to understand how a complex biological system responds to subtle perturbations in its environment. We have examined the temporal response of the dermal and epidermal layers of an irradiated 3D full thickness skin model using transcriptomic, proteomic, phosphoproteomic and metabolomic strategies to generate a significant amount of heterogeneous data. The integration of these varied data sets using both top down and bottom up approaches identified novel signaling pathways that would not be clearly observed by any single ‘omic technology and suggests persistent alterations in cellular and tissue homeostatic regulation occur following low dose radiation exposures in skin. The goal of these systems approaches is to enable a transition from qualitative observations to a quantitative and ultimately predictive science.
Overview of the Liulin type instruments for space radiation measurement and their scientific results
T.P. Dachev, J.V. Semkova, B.T. Tomov, Yu.N. Matviichuk, P.G. Dimitrov, R.T. Koleva, St.Malchev, N.G. Bankov, V.A. Shurshakov, V.V. Benghin, E.N. Yarmanova, O.A. Ivanova, D.-P. Häder, M. Lebert, M.T. Schuster, G. Reitz, G. Horneck, Y. Uchihori, H. Kitamura, O. Ploc, J. Cubancak, I. Nikolaev, Life Sciences in Space Research, Volume 4, January 2015, Pages 92–114.
The paper presents an overview of the different modifications of the Liulin type spectrometer-dosimeters, which were developed in the late 1980s and have been in use since then. Up to now Liulin type instruments were developed for 14 experiments in space: 1 on Mir space station, 6 on ISS, and other 7 on different satellites including Chandrayaan-1 satellite at 100 km orbit around the Moon. 2 of them were lost on Mars-96 and Phobos-Grunt missions. Currently there are 3 active Liulin type experiments on ISS. The data analysis procedure allows characterization of the different main space radiation sources as GCR, inner radiation belt protons and outer radiation belt electrons. There are two major discoveries in the ISS radiation environment: the first is the large outside doses from relativistic electrons in the outer radiation belt, while the second is the decrease in the ISS SAA dose rate during the US space shuttle dockings. Liulin spectrometers were also used by different scientific groups for monitoring of the radiation environment on thousands of aircraft flights and balloons. The main advantages of the Liulin type spectrometers are their low weight (100–500 g), low power consumption (100–500 mW) and low cost.
Relative Effectiveness at 1 Gy after Acute and Fractionated Exposures of Heavy Ions with Different Linear Energy Transfer for Lung Tumorigenesis
Ya Wang, Xiang Wang, Alton B. Farris III, Ping Wang, Xiangming Zhang, Hongyan Wang, and (2015), Radiation Research: February 2015, Vol. 183, No. 2, pp. 233-239.
Lung cancer is the most commonly diagnosed cancer as well as the leading cause of cancer death in humans; therefore, studying radiation-induced lung tumorigenesis is critical for estimating the risk of space radiation to astronauts. In this study, we show that all these tested HZE particles (iron, silicon, oxygen) induced a higher incidence of lung tumorigenesis than x-rays, the relative effectiveness at 1 Gy was > 6 and silicon exposure induced more aggressive lung tumors.
Novel images and novel locations of familiar images as sensitive translational cognitive tests in humans
J. Raber. published in Behav Brain Res. 2015 Feb 2. [Epub ahead of print].
Cognitive tests involving preferential exploration of familiar objects in novel locations and of novel objects are particularly sensitive to detect effects of space irradiation in rodents. Based on the rodent test of object recognition, a human test of object recognition was developed, the Novel Image Novel Location (NINL) test, containing panels with three images each. As this test does not involve language and is sensitive to detect of apolipoprotein E4, a risk factor for age-related cognitive decline and Alzheimer’s disease, in the healthy oldest-old (mean age 81 years), it would also be good to consider the NINL test for assessing cognitive performance in astronauts during and/or following space missions.
Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy - The heavy burden to repair
Rübe CE, Lorat Y, Brunner CU, Schanz S, Jakob B, Taucher-Scholz G. DNA Repair (Amst). 2015 Jan 28. pii: S1568-7864(15)00019-1. doi: 10.1016/j.dnarep.2015.01.007.
The spatial distribution of energy deposition on the scale of DNA, cells and tissue for both low- and high-LET radiation is important in determining the subsequent biological response in DNA, cells and ultimately people. In irradiated cells, the biological response has been shown to be critically dependent on the clustering of DNA damage on the nanometer scale, with high-LET radiation not only producing a higher frequency of complex DNA damage but also typically producing damage sites of greater complexity than those produced by low-LET radiation.
Here, using a new approach based on electron microscopic detection of immunogold-labeled repair factors we visualized different types of DNA lesions (SSBs, DSBs, clustered lesions) in the chromatin ultrastructure of human cells and characterized the spatio-temporal DNA damage pattern at the nanometer scale after low-LET and high-LET radiation. We show that high-LET radiation produced highly clustered DNA lesions within the particle trajectories, with multiple DSBs localized in regions of compact heterochromatin. Compared to sparsely ionizing radiation, high-LET radiation induced clearly higher yields of DSBs with up to ~500 DSBs per µm3 track volume. These clustered DNA lesions were repaired with slower kinetics and large fractions of these heterochromatic DSBs remained unrepaired. These unrepaired and/or misrepaired DNA lesions may contribute to the observed higher relative biological effectiveness for cell killing, chromosomal aberrations, mutagenesis, and carcinogenesis in high-LET radiated cells.
Previous In the News Items
A lifetime in biophysics
Blakely E., CERN COURIER. Aug 26, 2014
Eleanor Blakely talks about her work at Berkeley that began with pioneering research into the use of ion beams for hadron therapy.
Low- and High-LET Radiation Drives Clonal Expansion of Lung Progenitor Cells In Vivo
Farin, A. M., Manzo, N. D., Terry, K. L., Kirsch, D. G. and Stripp, B. R. Radiat. Res. 183,124–132 (2015).
Astronauts are exposed to varying doses and qualities of ionizing radiation during space travel. However, little is known about the effects of ionizing radiation on epithelial progenitor cells that maintain the respiratory system. We hypothesized that ionizing radiation exposure would compromise progenitor cell function leading to changes in their capacity for epithelial maintenance. We assessed progenitor cell function and capacity for clonal expansion following exposure to either X-rays or 56Fe using genetic lineage tracing in combination with in vitro and in vivo assays. We found that progenitor cells were lost in a radiation dose and quality-dependent manner, but surviving progenitor cells undergo significant clonal expansion for epithelial maintenance. Based on our data, we propose a model in which radiation induces a dose-dependent decrease in the pool of available progenitor cells, leaving fewer progenitors able to maintain the airway long-term.
Understanding Cancer Development. Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair, and Inflammation
Sridharan, D. M., Asaithamby, A., Bailey, S. M., Costes, S., Doetsch, P. W., Dynan, W., Kronenberg, A., Rithidech, K. N.,Saha, J., Snijders, A. M., Werner, E., Wiese, C., Cucinotta, F.A. and Pluth, J. M. Radiat. Res. 183, 1–26 (2015).
Oxidative stress appears to play a central role in DNA damage, telomere dysfunction and inflammation as redox reactions regulate several critical biological processes. We have attempted to clarify how redox regulation is central in influencing biological response, cell fate and potentiating cancer risk especially in cells exposed to space radiation. This review summarizes our current understanding of some critical areas within the DNA damage and oxidative arena that are key aspects to more fully elucidate in order to obtain useful robust tools to accurately model cancer risk.
Effect of Radiation Quality on Mutagenic Joining of Enzymatically-Induced DNA Double-Strand Breaks in Previously Irradiated Human Cells. Radiation Research:
Zhentian Li, Huichen Wang, Ya Wang, John P. Murnane, and William S. Dynan (2014) November 2014, Vol. 182, No. 5, pp. 573-579.
Prior work has shown that exposure of mammalian cells to HZE-particle radiation predisposes them to inaccurately repair new DNA double-strand breaks induced experimentally at various times during recovery. The effect was seen originally when a human tumor reporter cell line was exposed to 600 MeV/u 56Fe particles (LET = 174 keV/micron), then challenged by expression of the rare-cutting endonuclease, I-SceI. HZE particle irradiation increased the frequency of I-SceI-mediated deletions and translocations relative to non-irradiated, or low-LET irradiated, controls. Here, we tested two additional ions, 1000 MeV/u 48Ti (LET = 108 keV/micron) and 300 MeV/u 28Si (LET = 69 keV/micron). Exposure to 48Ti increased the frequency of translocations, but not deletions, whereas the 28Si ions had no measurable effect on either endpoint. There was a close correlation between the induction of the mutagenic repair phenomenon and the frequency of micronuclei in the targeted population, whereas there was no apparent correlation with radiation-induced cell inactivation. Together, results better define the radiation quality dependence of the mutagenic repair phenomenon and establish its correlation, or lack of correlation, with other endpoints.
Impact of breathing 100% oxygen on radiation-induced cognitive impairment.
Wheeler K, Payne V, D' Agostino R, Walb M, Munley M, Metheny-Barlow L, Robbins M. Radiation Research: November 2014, Vol. 182, No. 5, pp. 580–585
Astronauts are exposed to space radiations while breathing 100% oxygen during an EVA. Given that brain irradiation can cause cognitive impairment and oxygen is a potent radiosensitizer, astronauts may have a greater risk of developing radiation-induced cognitive impairment during an EVA. In this study, unanesthetized and unrestrained rats were whole-body irradiated with 18 MV X-rays at a low dose rate of ~425 mGy/min while breathing either air or 100% oxygen for 30 min before, during and 2 h postirradiation. Within the study's limitations, breathing 100% oxygen under simulated EVA conditions, increased rather than decreased, cognitive function at all doses when compared to irradiated air-breathing rats. Thus, astronauts are not likely to be at a greater risk of developing cognitive impairment when exposed to space radiations while breathing 100% oxygen during an EVA.
Does the worsening galactic cosmic radiation environment observed by CRaTER preclude future manned deep space exploration?
N. A. Schwadron, J. B. Blake, A. W. Case, C. J. Joyce1, J. Kasper, J. Mazur, N. Petro, M. Quinn, J. A. Porter, C.W. Smith, S. Smith, H. E. Spence, L.W. Townsend, R. Turner, J. K.Wilson, and C. Zeitlin. Space Weather (online), 11, doi:10.1002/2014SW001084
Data from a cosmic ray telescope onboard NASA's Lunar Reconnaissance Orbiter show that while increasing fluxes of cosmic rays "are not a show stopper for long duration missions (e.g., to the Moon, an asteroid, or Mars), galactic cosmic radiation remains a significant and worsening factor that limits mission durations.”
Cosmic rays are intensifying. Galactic cosmic rays are a mixture of high-energy photons and subatomic particles accelerated to near-light speed by violent events such as supernova explosions. Astronauts are protected from cosmic rays in part by the sun: solar magnetic fields and the solar wind combine to create a porous 'shield' that fends off energetic particles from outside the solar system. The problem is "The sun and its solar wind are currently exhibiting extremely low densities and magnetic field strengths, representing states that have never been observed during the Space Age. As a result of the remarkably weak solar activity, we have also observed the highest fluxes of cosmic rays in the Space Age."
The shielding action of the sun is strongest during solar maximum and weakest during solar minimum. At the moment we are experiencing Solar Max, which should be a good time for astronauts to fly. However, the solar maximum of 2011-2014 is the weakest in a century, allowing unusual numbers of cosmic rays to penetrate the solar system.
This situation could become even worse if, as some researchers suspect, the sun is entering a long-term phase of the solar cycle characterized by relatively weak maxima and deep, extended minima. In such a future, feeble solar magnetic fields would do an extra-poor job keeping cosmic rays at bay, further reducing the number of days astronauts can travel far from Earth.
NCRP Commentary No. 23, Radiation Protection for Space Activities: Supplement to Previous Recommendations.
National Council on Radiation Protection and Measurements. Bethesda, MD. November 18, 2014.
This Commentary supplements previous recommendations from NCRP that underlie the current National Aeronautics and Space Administration (NASA) standards for radiation protection of crew members during space activities. This Commentary focuses on the implications of extended LEO missions in a general manner, particularly with regard to uncertainties in the knowledge of the health effects and the biological effectiveness of exposures to galactic cosmic rays in space, and includes a discussion of ethical considerations and principles that may bear on the application of NCRP advice on radiation protection for space activities. The Commentary is available from the NCRP website.
Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53 Null Mammary Carcinomas.
Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes SV, Demaria S, Barcellos-Hoff MH. Cancer Res. 2014 Oct 10. pii: canres.1212.2014.
Ionizing radiation is a complete carcinogen, able to both initiate malignant transformation by causing mutations in cells and to promote cancer progression by acting systemically via the tissue microenvironment. Here, the authors use a radiation mammary chimera, in which the host is irradiated but the mammary epithelium is not, to demonstrate that densely ionizing radiation (350 MeV/amu Si) acts via the microenvironment to promotes development of aggressive mammary tumors. Compared to sham-irradiated mice, a class of hormone receptor negative tumors grew faster and were more metastic in Si-particle irradiated mice. This study suggests that the response of tissues to densely ionizing radiation is an important component of its carcinogenic action; unlike mutations per se, the response of the microenvironment is amenable to countermeasures.
New tricks for an old fox: impact of TGFβ on the DNA damage response and genomic stability.
M. H. Barcellos-Hoff, F. A. Cucinotta, (2014) Sci. Signal. 7, re5.
Transforming growth factor beta is a pleiotropic growth factor necessary for homeostasis and responses to injury. TGFbeta activity is controlled by its secretion as a latent complex that is extracellularly activated by reactive oxygen species, engendering rapid and persistent mediation of tissue responses to radiation. Here, the authors review how TGFb signaling is also involved in the efficient execution of the DNA damage response, which ties the intrinsic molecular mechanisms maintaining DNA integrity to extrinsic control of tissue function.
Induction of Chromosomal Aberrations at Fluences of Less Than One HZE Particle per Cell Nucleus. Megumi Hada, Lori J.
Chappell, Minli Wang, Kerry A. George, and Francis A. Cucinotta (2014) Radiation Research: October 2014, Vol. 182, No. 4, pp. 368–379.
We investigated the dose response for chromosomal aberrations for exposures corresponding to less than one particle traversal per cell nucleus by high-energy charged (HZE) nuclei. Nonlinear regression models were used to evaluate possible linear and nonlinear dose-response models based on these data. Dose responses for simple exchanges for human fibroblasts were best fit by nonlinear models motivated by a nontargeted effect (NTE). The best fits for dose response data for human lymphocytes were a linear response model for all particles. Our results suggest that simple exchanges in normal human fibroblasts have an important NTE contribution at low-particle fluence. The current and prior experimental studies provide important evidence against the linear dose response assumption used in radiation protection for HZE particles and other high-LET radiation at the relevant range of low doses.
Description and Verification of an Algorithm for Obtaining Microdosimetric Quantities for High-LET Radiation Using a Single TEPC without Pulse Height Analysis.
Thomas B. Borak and Phillip L. Chapman (2014) Radiation Research: October 2014, Vol. 182, No. 4, pp. 396–407.
Microdosimetric spectra of single event distributions have been used to provide estimates of quality factors for radiation protection of high LET radiation. It becomes difficult to measure, record and store energy deposition from single events in situations with high dose rates. An alternative approach is to store random energy deposition events in a sequence of fixed time intervals that does not require recording single events. This can be accomplished with one detector without pulse shaping or pulse height analysis. We present the development of the algorithm using expectation analyses of the statistical estimators for moments of lineal energy. The method can provide prompt real-time information in circumstances that restrict detector configurations in terms of size, mass and power consumption such as personal dosimetry during an EVA. It can be adapted for measurements of any quantity that is linearly related to absorbed dose, such as estimation of dose averaged LET.
Radiation Quality and Mutagenesis in Human Lymphoblastoid Cells. Radiation Research
Howard L. Liber, Rupa Idate, Christy Warner, and Susan M. Bailey (2014) October 2014, Vol. 182, No. 4, pp. 390–395.
It seems logical that after exposures to low doses of HZE particles, damage to individual cells should be distributed as described by Poisson statistics. Cells with the most traversals and thus the highest probability of experiencing induced mutations would also be more likely to grow slowly during the expression period; these cells would be “diluted” by more rapidly growing, less damaged cells. This would lead to an underestimation of the actual level of induced mutations. In the manuscript, we showed that this was true, and went on to characterize induced mutations as a function of radiation quality — silicon at 400 MeV/n was the most mutagenic ion/energy. Interestingly, we found that induction of non-targeted mutagenesis had a pattern which appeared to be the mirror-image of that seen for direct effects.
Updates to Patrick M. O’Neill’s NASA Space Radiation Summer School Lecture The Natural Ionizing Space Radiation Environment have been posted to the THREE Encyclopedia -- Basic Concepts of Space Radiation.
Posted November 7, 2011
Mary Helen Barcellos-Hoff’s NASA Space Radiation Summer School lecture Systems Radiation Biology and Radiation Induced Cell Signals has been posted to the THREE Encyclopedia – Tissue Biology and Pathology.
Posted November 3, 2011
Congratulations to space radiation investigators Francis Cucinotta and Sylvain Costes, who have been elected Vice-President-Elect and Physics Councilor, respectively, for the Radiation Research Society.
Posted to the Archive, November 7, 2011.
Revisions to the NASA projection model for lifetime cancer risks from space radiation and new estimates of model uncertainties are described in NASA/TP-2011- 216155, Space Radiation Cancer Risk Projections and Uncertainties – 2010 by Francis A. Cucinotta, Myung-Hee Y. Kim, Lori J. Chappell.
Posted October 17, 2011
The article Acute Effects by Thomas M. Seed has been newly revised and is posted in the Health Effects section of the THREE Encyclopedia.
Posted to the Archive October 20, 2011.
Science Now reports a new study suggesting “worse space weather” – with more threats to astronauts -- during the next decades:
Posted September 26, 2011.
Updates to Astronaut Radiation Limits: Radiation Risks for Never-Smokers was published online by Rad Res, May 16, 2011. The article from the Space Radiation Program Laboratory at NASA Johnson Space Center recommends dose limits for astronauts that take into consideration age- and gender-specific dose limits for never-smokers.
Posted May 27, 2011.
On April 21, 2011, the International Commission on Radiological Protection (ICRP) issued new recommendations on radiological protection. The Commission has now reviewed recent epidemiological evidence suggesting that there are some tissue reaction effects, particularly those with very late manifestation, where threshold doses are or might be lower than previously considered. For the lens of the eye, the threshold in absorbed dose is now considered to be 0.5 Gy. Accordingly, (3) For occupational exposure in planned exposure situations the Commission now recommends an equivalent dose limit for the lens of the eye of 20 mSv in a year, averaged over defined periods of 5 years, with no single year exceeding 50 mSv. In part, the new recommendations are based on research reported by NASA scientists:
- Chylack LT Jr, Peterson LE, Feiveson AH, Wear ML, Manuel FK, Tung WH, Hardy DS, Marak LJ, Cucinotta FA (2009) NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity. Radiat Res 172(1) 10-20 and
- Cucinotta FA, Manuel FK, Jones J, Iszard G, Murrey J, Djojonegro, Wear ML (2001). Space radiation and cataracts in astronauts. Radiat Res 156(5) 460–466.
The full draft report may be found at Annals of the ICRP.
A new text by Dr. Olga Smirnova, Environmental Radiation Effects on Mammals: A Dynamical Modeling Approach , has been published by Springer. Read more. Posted to the Archive, May 27, 2011.
Feature article on Radiation Risk in Technology Innovation, NASA’s magazine for Business & Technology, Volume 15 Number 3, 2010. Posted to the Archive, May 17, 2011.
Mitigating Astronauts’ Health Risks from Space Radiation
Francis A. Cucinotta, Ph.D.
NASA Space Radiation Summer School Slide Notes Competition
2012 Annual NASA Space Radiation Summer School Slide Competition
2011 Annual NASA Space Radiation Summer School Slide Competition
2010 Annual NASA Space Radiation Summer School Slide Competition
Glossary derived from:
Human Research Program Integrated Research Plan, Revision A, (January 2009). National Aeronautics and Space Administration, Johnson Space Center, Houston, Texas 77058, pages 232-280.
Exploration Systems Radiation Monitoring Requirements (Sept 2012). Page ii. Ronald Turner.
Report No. 153: Information Needed to Make Radiation Protection Recommendations for Space Missions Beyond Low-Earth Orbit (2006). National Council on Radiation Protection and Measurements, pages 309-318. Reprinted with permission of the National Council on Radiation Protection and Measurements.
Managing Space Radiation Risk in the New Era of Space Exploration (2008). Committee on the Evaluation of Radiation Shielding for Space Exploration, National Research Council. National Academies Press, pages 111-118.
Contents: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
AAPM: American Association of Physicists in Medicine.
absolute risk: Expression of excess risk due to exposure as the arithmetic difference between the risk among those exposed and that obtaining in the absence of exposure.
absorbed dose (D): Average amount of energy imparted by ionizing particles to a unit mass of irradiated material in a volume sufficiently small to disregard variations in the radiation field but sufficiently large to average over statistical fluctuations in energy deposition, and where energy imparted is the difference between energy entering the volume and energy leaving the volume. The same dose has different consequences depending on the type of radiation delivered. Unit: gray (Gy), equivalent to 1 J/kg.
ACE: Advanced Composition Explorer Mission, launched in 1997 and orbiting the L1 libration point to sample energetic particles arriving from the Sun and interstellar and galactic sources. It also provides continuous coverage of solar wind parameters and solar energetic particle intensities (space weather). When reporting space weather, it can provide an advance warning (about one hour) of geomagnetic storms that can overload power grids, disrupt communications on Earth, and present a hazard to astronauts.
acute effects: short-term biological effects of exposure to radiation, including headaches, dizziness, nausea, and illness that can range from mild to fatal.
acute exposure: Radiation exposure of short duration.
AGS: Alternating Gradient Synchrotron (at Brookhaven National Laboratory).
ALARA (As Low As Reasonably Achievable): An essential operational safety requirement, as well as a regulatory requirement, that emphasizes keeping exposure to radiation as low as possible using reasonable methods, and not treating dose limits as “tolerance values”; defined at NASA as limiting radiation exposure to a level that will result in an estimated risk below the limit of the 95 percent confidence level.
albedo: secondary radiation produced by interactions of galactic cosmic rays and high-energy solar protons with matter in the atmosphere or on the surface.
ALL: acute lymphocytic leukemia.
alpha particle: An energetic charged nucleus consisting of two protons and two neutrons. This particle is identical to the 4He nucleus.
ALTEA: Anomalous Long-Term Effects in Astronauts study .
AM: amplitude modulation.
AMA: American Medical Association.
AMAC: American Medical Advisory Committee.
AML: acute myelogenous leukemia.
Amu: atomic mass unit (ALSO : u).
ANLL: acute nonlymphocytic leukemia.
annual risk: The risk in a given year from an earlier exposure. The annual risk (average) from an exposure is the lifetime risk divided by the number of years of expression.
ANP: atrial natriuretic peptide.
ANS: American Nuclear Society.
ANSI: American National Standards Institute.
AU: Astronomical Unit (distance from the Earth to the Sun)
Apoe4: Apoliprotein E isoform 4. Modification of Apo4 is major risk factor in Alzheimer's disease.
apoptosis: A specific mode of cell death (also known as programmed cell death) that can be triggered by exposure to radiation, especially in cells of lymphoid/myeloid or epithelial lineage. Extensive apoptosis contributes to the hematopoietic and gastrointestinal symptoms seen in acute radiation syndrome.
ARC: NASA Ames Research Center.
Ares V/Heavy Lift Launch Vehicle: a NASA vehicle intended to deliver cargo from Earth to low Earth orbit.
ARM: Atmospheric Radiation Measurements.
ascent stage: The pressurized upper stage of the Lunar Lander in which the crew pilots the lander from lunar orbit to the lunar surface and return. The ascent stage takes off from the descent stage, leaving the latter behind on the surface.
AT: ataxia telangiectasia.
ATM: ataxia telangiectasia mutated.
AU: Astronomical Unit (Approx. distance from the Earth to the Sun)
AX-2: NASA Ames Research Center Experimental Suit 2, designed during the Apollo program as a lunar surface hard suit to bend at the waist and rotate in the torso so that the crew member can reach down to the ground with one hand. Fabricated from fiberglass.
AX-5: NASA Ames Research Center Experimental Suit 5, designed during the Space Station Advanced Development program to provide a durable hard suit for extended operations in zero gravity. Fabricated from numerically milled aluminum forgings.
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background radiation: The amount of radiation to which a member of the population is exposed from natural sources, such as terrestrial radiation from naturally-occurring radionuclides in the soil, cosmic radiation originating in outer space, and naturally-occurring radionuclides deposited in the human body. The natural background radiation received by an individual depends on geographic location and living habits. In the United States, the background radiation is on the order of 1 mSv y–1, excluding indoor radon which amounts to ~2 mSv/year on average.
BAF: Booster Applications Facility (the name used to designate the NSRL during planning and construction phases).
BaRyoN: Quark bound state with zero strangeness.
BCC: basal cell carcinoma.
BCD: budget change directive.
BEIR: Biological Effects of Ionizing Radiation. One of a series of reports on the health risks from exposure to low levels of ionizing radiation issued by the Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation, Board on Radiation Effects, Research Division on Earth and Life Studies, National Research Council of the National Academies of Science of the United States, referred to by a Roman number denoting its position in the sequence of reports. At the time of this writing, the latest report is BEIR VII.
BEVALAC: An accelerator system at Lawrence Berkeley National Laboratory consisting of the Bevatron (an early, high-energy synchrotron accelerator constructed in the 1950s and used to discover the antiproton), accelerating particles delivered by the SuperHILAC (first built as the HILAC - Heavy Ion Linear Accelerator - in 1957; along with a similar one at Yale University, the first machine in the US built specifically to accelerate heavy ions, completely rebuilt into the SuperHILAC in 1971). Closed in 1993.
biological end point: effect or response being assessed, e.g., cancer, cataracts.
bipolar device: a type of semiconductor whose operation is based on both majority and minority carriers.
BNL: Brookhaven National Laboratory in Upton (Long Island), New York.
BRCA1: breast cancer 1 tumor suppressor gene.
BRCA2: breast cancer 2 tumor suppressor gene.
BRYNTRN: BaRYoN TRaNsport code, a computer code for simulating baryon transport.
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CAD: computer aided design.
CaLV: Cargo Launch Vehicle.
CAM: computerized anatomical man model.
carbon composite: a composite incorporating carbon and other materials for use in lightweight structures, strong enough to substitute for aluminum and other metals in the construction of many parts of a spacecraft, notably the pressure vessel shell. It may incorporate boron, epoxy, polyethylene, hydrogen, or other materials that enhance radiation shielding properties.
CARD: Constellation Architecture Requirements Document; CxP 7000
cargo habitat: a crew habitat that the Lunar Lander carries for delivery to the Lunar Outpost as a key part of the “Outpost-first” strategy considered by NASA as part of the Space Exploration Initiative program.
CB: Control Board.
CDC: Center for Disease Control and Prevention.
CEDE: committed effective dose equivalent.
CENELEC: European Committee for Electrotechnical Standardization.
CEQATR: Constellation Program Environmental Qualification and Acceptance Testing Requirements; CxP 70036
CERN: European Organization for Nuclear Research.
CEV: Crew Exploration Vehicle.
CFR: Code of Federal Regulations.
CHMO: Chief Health And Medical Officer (NASA).
chronic effects: long-lasting effects of exposure to radiation; includes cancer, cataracts, and nervous system damage.
chronic exposure: Radiation exposure over long times (continuous or fractionated).
CI: confidence interval.
CL: confidence level.
CLV: Crew Launch Vehicle.
CME: coronal mass ejection, an explosion of plasma released from the atmosphere (or corona) of the Sun.
CML: chronic myelogenous leukemia.
CNP: cyclic nucleotide phosphatase.
CNS: central nervous system.
Composites: materials made from two or more constituent materials with significantly different physical or chemical properties which remain separate and distinct at the macroscopic or microscopic scale within the finished structure.
computerized anatomical male/female: a model of human geometry used to evaluate radiation doses at various points inside the body.
Constellation system: the complete ensemble of launch vehicles, flight vehicles, ground support, support services, and lunar and planetary surface systems associated with the Vision for Space Exploration initiated during the Bush administration.
coronal mass ejection (CME): A transient outflow of plasma from or through the solar corona which may be associated with the generation of solar-particle events.
cosmic-ray modulation: The variation of the observed cosmic-ray intensity as a function of the solar cycle. The cosmic-ray intensity within the solar system is observed to vary approximately inversely with the solar activity cycle that controls the interplanetary magnetic field.
COTS: commercial, off-the-shelf.
CPD: crew passive dosimeter.
CPU: central processor unit.
CRaTER: Cosmic Ray Telescope for the Effects of Radiation.
CRCPD: Conference of Radiation Control Program Directors.
CREME96: Cosmic Ray Effects on Micro-Electronics (1996 revision), a computer code.
cross section (σ): probability per unit particle fluence of a given end point. Unit: cm2.
CT: computed tomography.
CTA: conditioned taste aversion.
CVD: cardiovascular disease.
CW: continuous wave.
CxP: Constellation Program.
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Dr: dose-rate (Gy/hr).
DAAC: Distributed Active Archive Center.
DDREF: dose and dose-rate effectiveness factor (the degree to which both dose and dose rate may influence the biological effects of exposure to a given dose of radiation).
delta rays: Electrons directly ejected from atoms in matter by radiation.
descent stage: The lower stage of the Lunar Lander that includes the descent and landing engines and propellant tanks to serve them. The crew ascending back to lunar orbit in the ascent stage leaves the descent stage behind on the lunar surface.
descent stage habitat: in the descent stage, a pressurized crew habitat in which the crew would live during sortie missions.
deterministic process: process whereby a given event will occur whenever its dose threshold is exceeded.
deterministic effects: early radiation effects usually related to a significant fraction of cell loss, exceeding the threshold for impairment of function in a tissue; so called because the statistical fluctuations in the number of affected cells are very small compared to the number of cells required to reach the threshold (ICRP 1991), above which the severity varies with dose.
detriment: Health detriment is the sum of the probabilities of all the components of health effects. These include in addition to fatal cancer the probability of heritable effects and the probability of morbidity from nonfatal cancer.
DHS: Department of Homeland Security.
DNA: deoxyribonucleic acid.
DOD: Department of Defense.
DOE: Department of Energy.
dose: A general term used when the context is not specific to a particular dose quantity. When the context is specific, the name or symbol for the quantity is used [i.e., absorbed dose (D), mean absorbed dose (DT), dose equivalent (H), effective dose (E), equivalent dose (HT), or organ dose equivalent].
dose equivalent (H): Estimate of radiation risk that accounts for differences in the biological effectiveness of different types of charged particles that produce the absorbed dose. H=Q × D, where Q is a quality factor based on the type of radiation (Q = 1 for x-rays). NASA uses Q as specified in ICRP Publication 60 (ICRP, 1991). Unit: sievert (Sv), equivalent to 1 J/kg.
dose limit: A limit on radiation dose that is applied by restricting exposure to individuals or groups of individuals in order to prevent the occurrence of radiation-induced deterministic effects or to limit the probability of radiation related stochastic effects to an acceptable level. For astronauts working in low-Earth orbit, unique dose limits for deterministic and stochastic effects have been recommended by NCRP.
dose rate: Dose delivered per unit time. Can refer to any dose quantity (e.g., absorbed dose, dose equivalent).
dose-response model: A mathematical formulation of the way in which the effect, or response, depends on dose.
dosimeter: A radiation detection device worn or carried by an individual to monitor the individual's radiation exposure. For space activities, a device worn or carried by an astronaut in-flight.
DREF: dose rate effectiveness factor (the degree to which dose rate may influence the biological effects of exposure to a given dose of radiation).
DRM: Design Reference Mission.
DSB: double strand break.
DSNE: Constellation Program Design Specification for Natural Environments; CxP 70023
DTRA: Defense Threat Reduction Agency.
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E: effective dose/ energy.
EAR:excess additive risk (cf. absolute risk).
ED50: dose to cause 50 % of the population to have the effect (e.g., nausea).
EDS: Earth departure stage.
effective dose (E): The sum over specified tissues of the products of the equivalent dose in a tissue (HT) and the tissue weighting factor for that tissue or organ (wT) (i.e., E = wTHT). Effective dose (E) applies only to stochastic effects. Unit: sievert (Sv), equivalent to 1 J/kg.
electron volt (eV): a unit of energy equivalent to 1.602 × 10–19 joules.
ELF: extremely low frequency.
ELR: excess lifetime risk.
EMF: electromagnetic field.
EML: Environmental Measurements Laboratory, New York, NY.
EMS: emergency medical services.
EMU: Extravehicular mobility unit, the space suit developed for space shuttle crews that also serves on the ISS. The EMU features a hard upper torso and soft lower torso, arms, and legs over the pressure bladder. The entire EMU except the helmets and boots is covered by the thermal micrometeoroid garment.
electron volt (eV): A unit of energy = 1.6 x 10–12 ergs = 1.6 x 10–19 J; 1 eV is equivalent to the energy gained by an electron in passing through a potential difference of 1 V; 1 keV = 1,000 eV; 1 MeV = 1,000,000 eV.
EOS: Earth Observing System.
EPA: Environmental Protection Agency.
equivalent dose (HT): The product of the mean absorbed dose in an organ or tissue and the radiation weighting factor (wR) of the radiation type of interest. For external exposure wR applies to the radiation type incident on the body.
ERR:excess relative risk.
erythema: A redness of the skin.
ESA: European Space Agency.
ESMD: Exploration Systems Mission Directorate (NASA).
ESP: energetic storm particle.
ESTEC: European Space Research and Technology Centre.
EVCPDS: Extra Vehicle Charged Particle Directional Spectrometer
excess relative risk (ERR): The ratio between the total risk, including the increase due to radiation exposure, and the baseline risk in the absence of radiation exposure; if the excess equals the baseline the relative risk is two.
exposure (technical use): A measure of the ionization produced in air by x or gamma radiation. Exposure is the sum of electric charges on all ions of one sign produced in air when all electrons liberated by photons in a volume of air are completely stopped, divided by the mass of the air in the volume. The unit of exposure in air is the roentgen (R) or in SI units it is expressed in coulombs (C), 1 R = 2.58 x 10–4 C/kg.
exposure (non-technical use): the presentation of an individual or material to radiation likely to deliver a significant dose over a period of time.
EVA: extravehicular activity.
excess risk: the increase in the probability of a certain effect on an individual who has been exposed to a given dose of radiation over the probability of that effect in the absence of radiation exposure.
extravehicular activity: Any activity undertaken by the crew outside a space vehicle or habitat.
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favorable propagation path: A concept suggesting that the Archimedean spiral path from the earth to the sun would connect to a specific solar longitude. It is based on the concept that charged particles travel along the interplanetary magnetic field which is transported out from the sun. For an idealized constant speed solar wind flow, if the interplanetary magnetic field is frozen in the plasma, then the result would form an Archimedean spiral.
FEMA: Federal Emergency Management Agency.
FIRE: First ISCCP Regional Experiment.
first ionization potential: The energy required to remove the least bound electron from an electrically neutral atom. (The ionization potential is usually given in electron volts.)
FISH: fluorescence in situ hybridization.
fluence: (1) ICRU definition: The quotient of dN by da, where dN is the number of particles incident on a sphere of cross-sectional area da (i.e., Φ = dN/da). The unit for fluence is 1/m2, but cm–2 is frequently used; (fluence may be a function of one or more other variables [e.g., Φ (L,t), the distribution of fluence as a function of linear energy transfer (L) and time (t)]. (2) planar fluence (F): The net number of charged particles traversing a given area. Unit: particles/cm2.
fluence rate (dF/dt): Change in fluence over a given small time interval, or the time derivative of the fluence. Unit: 1/m2s.
FLUKA: a general purpose Monte-Carlo computer code for calculations of particle transport and interactions with matter
flux (Φ): Term used historically by the nuclear community for fluence rate and also used for particle flux density, but deprecated by the ICRU convention to eliminate confusion between the terms “particle flux density” and “radiant flux.” See fluence rate.
FM: frequency modulation.
fractionation: The delivery of a given total dose of radiation as several smaller doses, separated by intervals of time.
FSP: fission surface power.
FY: Fiscal Year.
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galactic cosmic rays: the components of galactic cosmic radiation.
galactic cosmic radiation (GCR): The charged-particle radiation outside the Earth magnetosphere comprised of 2 % electrons and positrons, and 98 % nuclei, the latter component consisting (by fluence) of 87 % protons, 12 % helium ions, and 1 % high atomic number, high-energy (HZE) particles.
gamma rays: Short-wavelength electromagnetic radiation of nuclear origin (approximate range of energy: 10 keV to 9 MeV).
GCR: galactic cosmic radiation/ galactic cosmic rays.
GCR: galactic cosmic radiation.
GEANT: A computer application for the simulation of the passage of particles through matter including detector description and simulation.
GEO: Geostationary or Geosynchronous Earth Orbit.
Geostationary Operational Environmental Satellite (GOES): A satellite in geosynchronous orbit used for monitoring protons. The satellite travel at the same angular speed above the equator as Earth’s rotation and therefore appears stationary when observed from Earth’s surface.
GGTP: gamma-glutamyl transpeptidase.
GLE: ground level event.
GM: geometric mean.
GPM: Global Precipitation Measurement.
gray (Gy): The International System (SI) unit of absorbed dose of radiation, 1 Gy = 1 J kg–1.
gray equivalent (GT or Gy-Eq): The product of DT and Ri, where DT is the mean absorbed dose in an organ or tissue and Ri is a recommended value for relative biological effectiveness for deterministic effects for a given particle type i incident on the body ( GT = Ri × DT). The SI unit is J/kg (NCRP, 2000).
GSD: geometric standard deviation (the standard deviation of the logarithms of a set of random variables, for which the geometric mean is the square root of their product.
GSI(Gesellschaft für Schwerionenforschung): Helmholtz Centre for Heavy Ion Research in Darmstadt, Germany.
GSM: global system for mobile communications.
GT: gray equivalent.
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HACD: Human Adaptation and Countermeasures Division.
HDPE: high-density polyethylene, defined as having a density greater than 0.94 g/cm3 .
heavy charged particles: Atomic and subatomic charged particles with masses substantially heavier than that of an electron.
heavy ions: Nuclei of elements heavier than helium such as nitrogen, carbon, boron, neon, argon or iron which are positively charged due to some or all of the atomic electrons having been stripped from them.
HEDS: Human Exploration and Development of Space.
HEFD: Habitability and Environmental Factors Division.
heliocentric: A measurement system with its origin at the center of the sun.
heliolongitude: Imaginary lines of longitude on the sun measured east (left) or west (right) of the central meridian (imaginary north-south line through the middle of the visible solar disk) as viewed from Earth. The left edge of the solar disk is 90°E and the right edge is 90°W.
heliosphere: The magnetic bubble containing the solar system, solar wind, and entire solar magnetic field. It extends beyond the orbit of Pluto.
HEPAD: High Energy Proton and Alpha Detector.
HIDH: Human Integration Design Handbook; NASA/SP-2010-3407
high atomic number, high-energy (HZE) particles: Heavy ions having an atomic number greater than that of helium (such as nitrogen, carbon, boron, neon, argon or iron ions that are positively charged) and having high kinetic energy.
high-LET: Radiation having a high-linear energy transfer; for example, protons, alpha particles, heavy ions, and interaction products of fast neutrons.
HIMAC: Heavy Ion Medical Accelerator, Chiba Japan.
HMF: heliospheric magnetic field.
HPC: Hydrological Process and Climate.
HPRT: hypoxanthine-guanine phosphoribosyl transferase.
HRP: Human Research Program.
HRP CB: Human Research Program Control Board.
HSIR: Constellation Program Human Systems Integration Requirements; CxP 70024
HT: equivalent dose.
HZE: high atomic number and energy.
HZETRN: a transport code developed specifically for high-charge, high-energy particles that is widely used for space radiation shielding and design calculations.
HZE: high atomic number, high energy/ highly energetic, heavy, charged particles.
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IACUC: Institutional Animal Care and Use Committee.
IAEA: International Atomic Energy Agency.
ICNIRP: International Commission on Non-Ionizing Radiation Protection.
ICRP: International Commission on Radiation Protection.
ICRU: International Commission on Radiation Units and Measurements.
IDIQ: Indefinite delivery/indefinite quantity.
IEEE: Institute of Electrical and Electronics engineers.
incidence: The rate of occurrence of a disease, usually expressed in number of cases per million.
IND: improvised (or otherwise acquired) nuclear device.
interplanetary magnetic field: The magnetic field in interplanetary space. The interplanetary magnetic field is transported out from the sun via the solar wind.
interplanetary shocks: An abrupt change in the velocity or density of charged particles moving faster than the wave propagation speed in interplanetary space, so that higher velocity components bunch into lower velocity components before these can get out of the way.
ionizing radiation: Any electromagnetic or particulate radiation capable of producing ions, directly or indirectly, in its passage through matter.
ionization: The process by which a neutral atom or molecule acquires a positive or negative charge through the loss or gain of one or more orbital electrons.
IPT: Integrated Product Team.
IRMA: Integrated Risk Management Application.
ISCCP: International Satellite Cloud Climatology Project.
ISS: International Space Station.
ISSMP: ISS Medical Project.
ITA: Internal Task Agreement.
IVCPDS: Intra Vehicle Charged Particle Directional Spectrometer
IV & V: Independent Validation & Verification.
IWG: Investigator Working Group.
IWS: Investigator Workshop.
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JSC: NASA Johnson Space Center.
JWST: James Webb Space Telescope.
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kerma: (an acronym for “Kinetic energy released in materials;” the sum of the initial kinetic energies for all charged particles released by uncharged ionizing radiation in a small sample of material divided by the mass of the sample. Kerma is the same as dose when charged particle equilibrium exists (i.e., when, on the average, the number of charged particles leaving the sample is compensated by an equal number of charged particles entering the sample).
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LAP: latency associated peptide.
LAR: lifetime attributable risk.
LaRC: NASA Langley Research Center.
LAT: Lunar Architecture Team.
latchup: an anomalous state in a semiconductor in which the device no longer responds to input signals.
latent period: Period or state of seeming inactivity between time of exposure of tissue to an injurious agent and an observed response (also time to response or induction period).
LBNL: Lawrence Berkeley National Laboratory.
LCD: liquid crystal display.
LCVG: liquid cooling and ventilation garment.
LDEF: Long Duration Exposure Facility.
LDL: low-density lipoproteins.
LEND: Low Energy Neutron Detector.
LEO (low Earth orbit): the environment in which most recent space missions have been concentrated, where the magnetic field of Earth provides protection against much of the radiation that would be encountered on more distant exploration missions, approximately 300 to 600 mile orbit radius.
LET (linear energy transfer): Measure of the average local energy deposition per unit length of distance traveled by a charged particle in a material. Unit: keV/μm.
lifetime risk: The lifetime probability of suffering from the consequences of a specific health effect. The total risk in a lifetime resulting from an exposure(s) is equal to the average annual risk times the period of expression.
light ions: Nuclei of hydrogen and helium which are positively charged due to some or all of the planetary electrons having been stripped from them.
lineal energy (y): The quotient of ε by , where ε is the energy imparted to the matter in a given volume by a single (energy deposition) event and is the mean chord length of that volume (i.e., y = ε/ l ). The unit for lineal energy is J /m, but keV/ μm is often used in practice (1 keV/µm ~ 1.6x10-10 J/m).
linear energy transfer (LET): Average amount of energy lost per unit of particle track length as an ionizing particle travels through material, related to the microscopic density distribution of energy deposited in the material and, therefore, a major characteristic of radiation leading to different effects for the same dose of ionizing radiation of different LET on biological specimens or electronic devices.
linear-quadratic model (also linear-quadratic dose-response relationship): expresses the incidence of (e.g., mutation or cancer) as partly directly proportional to the dose (linear term) and partly proportional to the square of the dose (quadratic term).
LIS: local interstellar energy spectrum.
LIS: local interstellar GCR spectrum.
LIS: Local interplanetary Spectra.
LLD: lower limit of detection.
LLU: Loma Linda University.
LLO: low lunar orbit.
lognormal: If the logarithms of a set of values are distributed according to a normal distribution the values are said to have a lognormal distribution, or be distributed log normally.
low-LET: Radiation having a low-linear energy transfer; for example, electrons, x rays, and gamma rays.
LRV: Lunar Roving Vehicle.
LSAC: Life Sciences Applications Advisory Committee.
LSS: Life Span Study.
LSS: Life-Span Study of the Japanese atomic-bomb survivors.
Lunar Lander: the Constellation system vehicle that will travel between the Orion and the surface of the Moon.
LWS: Living With a Star (a NASA program).
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MARIE: Mars Radiation Environment Experiment.
mass stopping power: (see stopping power).
MAT: Mars Architecture Team.
MCNPX: Monte Carlo N-Particle eXtended.
MDO: Multi-disciplinary Optimization.
mean absorbed (tissue) dose (DT): The mean absorbed dose in an organ or tissue, obtained by integrating or averaging absorbed doses at points in the organ or tissue.
mean-free path: The average distance between particle collisions with nuclei, atoms or molecules in a material. Also, the average distance between scattering events in interplanetary particle propagation.
MEEP: Mir Environment Effects Payload.
MEO: Medium Earth Orbit.
MeV: Mega-electron Volts: 106 electron volts
mFISH: Multiplex Fluorescence In Situ Hybridization.
Mir: The Russian (previously Soviet) orbital space station.
MISSE: Materials on International Space Station Experiment.
MML: mouse myelogenous leukemia.
MMOP: Multilateral Medical Operations Panel.
MOA: Memorandum of Agreement.
MODIS: Moderate Resolution Imaging Spectrometer.
MORD: Medical Operations Requirements Documents.
MOU: Memorandum of Understanding.
MRI: magnetic resonance imaging.
MS: Mission Systems
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NAR: Non-Advocate Review.
NAS: National Academy of Sciences.
NASA: National Aeronautics and Space Administration.
NCI: National Cancer Institute.
NCRP: National Council on Radiation Protection and Measurements.
NEDD: Constellation Program Natural Environment Definition for Design; CxP 70044
neutrons: Particles with a mass similar to that of a proton, but with no electrical charge. Because they are electrically neutral, they cannot be accelerated in an electrical field.
NIEL: Non-ionizing energy loss, also called displacement kerma. The total kerma can be divided into an ionizing component and a displacement, or NIEL, component.
NIH: National Institutes of Health.
NM: neutron monitor.
NOAA: National Oceanic and Atmospheric Administration.
noncancer: Health effects other than cancer (e.g., cataracts, cardiovascular disease) that occur in the exposed individual.
Nowcasting: prediction of total doses and the future temporal evolution of the dose once a solar particle event has begun.
NOVICE: Radiation Transport/Shielding Code.
NPR: NASA Procedural Requirements.
NRA: NASA Research Announcement.
NRC: National Research Council.
NRC: Nuclear Regulatory Commission (US).
NSBRI: National Space Biomedical Research Institute.
NSCOR: NASA Specialized Center of Research.
NSF: National Science Foundation.
NSRL: NASA Space Radiation Laboratory (at BNL).
NTE: Non-Targeted Effects.
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OBPR: Office of Biological and Physical Research.
OCHMO: Office of Chief Health and Medical Officer.
organ dose equivalent ( DET): The mean dose equivalent for an organ or tissue, obtained by integrating or averaging dose equivalents at points in the organ or tissue. It is the practice in the space radiation protection community to obtain point values of absorbed dose (D) and dose equivalent (H) using the accepted quality factor-LET relationship [Q(L)], and then to average the point quantities over the organ or tissue of interest by means of computational models to obtain the organ dose equivalent (DET ). For space radiations, NCRP adopted the organ dose equivalent as an acceptable approximation for equivalent dose (HT) for stochastic effects.
Orion Crew Exploration Vehicle: The Constellation system vehicle that will carry passengers in low Earth orbit, or from low Earth orbit to the Moon or Mars, and then back to Earth. Often referred to as CEV; in this report referred to as the Orion crew module.
OSHA: Occupational Safety and Health Administration.
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PC: Probability of Causation.
PCC: premature chromosome condensation.
PCS: personal communication system.
PDF: probability density function.
PDF: probability distribution function.
PE: Project Executive.
PEL (permissible exposure limit): Maximum amount of radiation to which an astronaut may be exposed. For terrestrial workers, PELs are legal limits, defined by OSHA. NASA PELs are set by the chief health and medical officer.
PET: positron emission tomography.
photosphere: The portion of the sun visible in white light. Also the limit of seeing down through the solar atmosphere in white light.
PI: Principal Investigator.
PLR: pressurized lunar rover.
PLSS: personal life support system.
PM: Project Manager.
PP: Project Plan.
PPBE: Planning, Programming, Budgeting and Execution.
PPS: proton prediction system/ pulses per second.
PRD: Passive Radiation Detector; Program Requirements Document.
prevalence: The number of cases of a disease in existence at a given time per unit of population, usually per 100,000 persons.
protons: The nucleus of the hydrogen atom. Protons are positively charged.
protraction: Extending the length of exposure, for example, the continuous delivery of a radiation dose over a longer period of time.
PS: Project Scientist.
PSD: Position-Sensitive Detector; also, Pulse Shape Discrimination.
PVAMU: Prairie View A&M University.
PW: pulsed wave.
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Q: quality factor.
Q(L): quality factor as a function of linear energy transfer.
Qleukemia: quality factor for estimating leukemia risks.
Qsolid: quality factor for estimating solid cancer risks.
QMSFRG: quantum multiple scattering fragmentation model.
quality factor (Q): The factor by which absorbed dose (D) at a point is modified to obtain the dose equivalent (H) at the point (i.e., H = Q D), in order to express the effectiveness of an absorbed dose (in inducing stochastic effects) on a common scale of risk for all types of ionizing radiation. There is a specified dependence [Q(L)] of the quality factor (Q) as a function of the unrestricted linear energy transfer (L) in water at the point of interest.
quasithreshold dose: The dose at which the extrapolated straight portion of the dose-response curve intercepts the dose axis at unity survival fraction.
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RAD: Radiation Assessment Detector.
RAM: Radiation Area Monitor.
radiation: 1. The emission and propagation of energy through space or through matter in the form of waves, such as electromagnetic, sound, or elastic waves; 2. The energy propagated through space or through matter as waves; radiation or radiant energy, when unqualified, usually refers to electromagnetic radiation; commonly classified by frequency— Hertzian, infrared, visible, ultraviolet, x and gamma rays; 3. Corpuscular emission, such as alpha and beta particles, or rays of mixed or unknown type, such as cosmic radiation.
radiation quality: A general term referring to the microscopic distribution of of the energy absorbed to yield a given total dose. For example, at resolutions of a few micrometers ionizing events will be more uniformly dispersed for gamma-ray radiation than for the neutron radiation, producing quantitatively different biological effects (see relative biological effectiveness).
radiation weighting factor (wR): A factor related to the relative biological effectiveness of different radiations in the calculation of equivalent dose (HT) (see equivalent dose), independently of the tissue or organ irradiated.
RBE (relative biological effectiveness): Measure of the effectiveness of a specific type of radiation for producing a specific biological outcome, relative to a reference radiation (generally, 250 kVp x-rays). For a defined endpoint, RBE = Dref/Dnew. For HZE particles, RBE generally is greater than 1, meaning that a lower dose of more effective HZE particles will have the same effect as a given dose of the reference radiation.
RCT: Radiation Coordination Team.
RDD: radiological dispersal device.
RDWG: Radiation Discipline Working Group.
regolith: A layer of loose, heterogeneous material covering solid rock on the surface of a moon or planet (including Earth).
REIC: risk of exposure-induced cancer incidence.
REID (risk of exposure induced death): Measure of risk used by NASA as a standard for radiation protection; reflects a calculation of the probability of death due to exposure to radiation in space.
relative biological effectiveness (cf. RBE)
relative risk (cf. excess relative risk)
REM: rapid eye movement.
RFI: request for information.
RHIC: Relativistic Heavy Ion Collider (at BNL).
RHO: Radiation Health Officer.
rigidity: The momentum of a charged particle per unit charge. Determines the curvature of the particle’s trajectory in a magnetic field. Two particles with different charge but the same rigidity will travel along a path having the same curvature in a given magnetic field.
risk: The probability of a specified effect or response occurring.
risk coefficient: The increase in the annual incidence or mortality rate per unit dose: (1) absolute risk coefficient is the observed minus the expected number of cases per person year at risk for a unit dose; (2) the relative risk coefficient is the fractional increase in the baseline incidence or mortality rate for a unit dose.
risk cross section: The probability of a particular excess cancer mortality per particle fluence (excluding delta rays).
risk estimate: The number of cases (or deaths) that are projected to occur in a specified exposed population per unit dose for a defined exposure regime and expression period; number of cases per person-gray or, for radon, the number of cases per person cumulative working level month.
roentgen: A unit of radiation exposure. Exposure in SI units is expressed in C kg–1 of air.
ROS: reactive oxygen species.
RRS: radiation Research Society.
RSNA: Radiological Society of North America.
R&T: Research and Technology.
RTG: radioisotope thermoelectric generator.
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SAA: South Atlantic Anomaly.
SACR: Science Advisory Committee on Radiobiology.
SAMPEX: Solar Anomalous and Magnetospheric Particle Explorer.
SAR: specific absorption rate.
SBIR: Small Business Innovation Research.
SCAR: Smoke/Sulfate Clouds and Radiation Experiment.
SCC: squamous cell carcinoma/ small cell cancer.
SCE: sister chromatid exchange.
SCLS: small cell lung carcinoma.
SD: single dose.
SD: standard deviation.
SDO: Solar Dynamic Observatory.
SEC: Space Environment Center. (NOAA).
secondary radiation: radiation that has been generated by the interaction of radiation with the atoms or nuclei of a traversed material.
SEE (single-event effect): a class of effects in which damage results from a single ionizing particle traversing a microelectronic device, rather than the accumulated impact of a large number of particles.
SEE: single event effect/ Space Environment and Effects Program.
SEER: surveillance, epidemiology, and end results.
SET: Space Environment Testbeds.
SEU (single event upset): a change of state caused by ions or electro-magnetic radiation striking a sensitive node in a micro-electronic device.
SFHSS: Space Flight Human Systems Standard; NASA-STD-3001
SGZ: subgranular zone.
SI: International System of Units.
sievert (Sv): The special name for the SI unit of effective dose (E), equivalent dose (HT), dose equivalent (H), and organ dose equivalent (DT ), 1 Sv = 1 J /kg.
SLSD: Space Life Sciences Directorate (NASA).
S&MA: Safety and Mission Assurance (NASA).
SMD: Science Mission Directorate (NASA).
SMO: Science Management Office (NASA).
SOHO: Solar and Heliospheric Observatory.
Solar cycle: The periodic variation in the intensity of solar activity, as measured, for example, by the numbers of sunspots, flares, CMEs, and SPEs. The average length of solar cycles since 1900 is 11.4 y.
solar flare: The name given to the sudden release of energy (often >1032 ergs) in a relatively small volume of the solar atmosphere. Historically, an optical brightening in the chromosphere, now expanded to cover almost all impulsive radiation from the sun.
solar-particle event (SPE): An eruption at the sun that releases a large number of energetic particles (primarily protons) over the course of hours or days. Signatures of solar energetic-particle events may include significant increases in types of electromagnetic radiation such as radio waves, x-rays, and gamma rays.
solar wind: The plasma flowing into space from the solar corona. The ionized gas carrying magnetic fields can alter the intensity of the interplanetary radiation.
SOMD: Space Operations Mission Directorate (NASA).
spallation: A high-energy nuclear reaction in which a high-atomic-number target nucleus is struck by a high-energy, light particle (typically a proton); this causes the target nucleus to break up into many components, releasing many neutrons, protons, and higher Z particles.
SPE (cf. solar particle event).
Space Radiation Analysis Group (SRAG): the radiation protection group at NASA’s Johnson Space Center, responsible for radiation monitoring, projecting exposures, and ensuring adherence to principles of ALARA for crews on spaceflight missions.
SPENVIS (SPace ENVironment Information System) : a series of computer programs developed by the European Space Agency for the simulation of radiation effects in flight.
SRA: Society for Risk Analysis.
SRAG: Space Radiation Analysis Group
sRBC: Serum deprivation response factor-related gene product that binds to C-kinase.
SRPE: Space Radiation Program Element (NASA).
SSA: Social Security Administration.
STEREO: Solar-Terrestrial Relations Observatory (NASA mission).
stochastic effects: radiation effects attributed to the consequences of changes caused by radiation in one or a few cells; so called because the statistical fluctuations in the number of initial cells are large compared to the number of cells observed when radiation effects, such as cancer, become manifest (ICRP 1991). The probability of occurrence, rather than the severity, is a function of radiation dose.
stochastic process: process whereby the likelihood of the occurrence of a given event can be described by a probability distribution.
stopping power (lineal stopping power): The quotient of the energy lost (dE) by a charged particle in traversing a distance (dx) in a material. Can also be expressed as mass stopping power by dividing the lineal stopping power by the density (ρ) of the material.
STS: Space Transportation System.
STTR: Small Business Technical Transfer Research.
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TEDE: total effective dose equivalent.
TEPC: tissue equivalent proportional counter.
TGF: transforming growth factor.
TIGER: Grid Generation Code.
tissue weighting factor (wT): A factor representing the ratio of risk of stochastic effects attributable to irradiation of a given organ or tissue to the total risk when the whole body is irradiated uniformly. The factor is independent of the type of radiation or energy of the radiation.
TLD: thermoluminescent dosimeter.
TMG: thermal micrometeoroid garment.
TMI: Three Mile Island.
TOGA/COARE: Tropical Ocean Global Atmosphere/Coupled Ocean-Atmosphere Experiment. transport (of radiation): the sequence of interactions between radiation traversing one or more materials and their atoms and nuclei; calculations of the relevant characteristics; transport code: computer program to calculate radiation transport.
trapped radiation: Ionized particles held in place by Earth’s magnetic fields. Also known as the Van Allen belt.
TRL: Technology Readiness Level.
TRMM: Tropical Rainfall Measuring Mission.
TVD: tenth-value distance.
TVL: tenth-value layer.
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UNSCEAR: United Nations Scientific Committee on the Effects Of Atomic Radiation.
US: United States.
USAF: United States Air Force.
US NRC: United States Nuclear Regulatory Commission.
USRA: Universities Space Research Association.
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vitreous: The semifluid, transparent substance which lies between the retina and the lens of the eye.
VSE: Vision for Space Exploration.
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WBS: Work Breakdown Structure.
WHO: World Health Organization.
Wind: a NASA spacecraft that observes the Sun and solar wind.
WL: working level.
WLM: working level month (170 h).
wR: radiation weighting factor.
wT: tissue weighting factor.
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Z: atomic number, the number of protons in the nucleus of an atom.
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